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What is the mechanism of action of spironolactone? Mechanism Of Action ALDACTONE (spironolactone) is a specific pharmacologic antagonist of aldosterone, acting primarily through competitive binding of receptors at the aldosterone-dependent sodium-potassium exchange site in the distal convoluted renal tubule.
How long should you take diuretics? You usually take gentle, long acting diuretics by mouth once each day in the morning. The effects of bendroflumethiazide (bendrofluazide) start within 1-2 hours of taking and can make you pass more urine for the first 14 days when taking it.
How long does it take for blood pressure meds to leave your system? The medication effects could be gone even though some medication is still in your blood. Most medications have a half-life of about 24 hours, so they are gone — or close to it — in 4-5 days.
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