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What medicine will stop a runny nose? Runny Nose, Watery Eyes, and Sneezing Over-the-counter antihistamines such as chlorpheniramine and diphenhydramine block this process and can relieve those symptoms. They can also make you sleepy and dry out your eyes, nose, and mouth.
What is the best nasal decongestant? Decongestants. These medicines help reduce the swelling in your nasal passages and ease the stuffiness and sinus pressure. They come as nasal sprays, like naphazoline (Privine), oxymetazoline (Afrin, Dristan, Nostrilla, Vicks Sinus Nasal Spray), or phenylephrine (Neo-Synephrine, Sinex, Rhinall).
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