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What should you avoid while taking methotrexate? Avoid drinking alcohol or keep alcohol intake to a minimum while taking methotrexate. If you are a woman with child-bearing potential, you should always use a reliable form of contraception while you are taking methotrexate. Your doctor may request that you take a pregnancy test before starting methotrexate.
How long do you take methotrexate for rheumatoid arthritis? 4. How long will methotrexate take to start working? It's not immediate. Many RA patients will start to experience an improvement in symptoms after six to eight weeks on methotrexate, but it can take up to six months before you would reach the full benefits of taking the drug.
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