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If your PSA level is under one nanogram per milliliter of blood and the doctor doesn't find anything wrong with your prostate, you may be able to go another 10 years without having another rectal exam. If your PSA is between one and two, however, Leavey recommends checking in every two years. Can prostate biopsy spread cancer? Two of every 100 men undergoing prostate biopsy will develop sepsis, a potentially lethal blood infection. Doctors and researchers have noted that biopsy of a tumor can cause seeding, or spread of cancer cells along the path of the needle track at the biopsy site. Does ibuprofen lower PSA? NSAIDs May Lower Prostate Cancer Markers Sept. 8, 2008 -- Regular use of aspirin, ibuprofen, and other anti-inflammatory pain relievers appears to lower blood levels of the prostate cancer biomarker prostate-specific antigen (PSA). Does every man get prostate cancer? All men are at risk of having prostate cancer. 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